Methylation Support

Vegetarian-friendly vitamin B complex
• Helps the body to metabolize carbohydrates, fats and proteins
• Helps in red blood cell and tissue formation
• Provides 50 mg of vitamin B₆, 801 mcg of vitamin B₁₂ and 400 mcg of folate (from Metafolin^®) per day
• Helps to prevent vitamin B₆, vitamin B₁₂, and folate deficiency

Methylation Support provides a combination of B vitamins, choline, and betaine to help support homocysteine level.¹ Homocysteine is an amino acid that can be further metabolized into methionine or cysteine.¹ Normal homocysteine levels are necessary for the methylation of nucleic acids, proteins and lipids, as well as protein production.¹ A randomized, double-blind trial involving 76 adults demonstrated that supplementation with 1.5 g of betaine daily for six weeks significantly better maintained homocysteine levels when compared to a placebo treatment.² Betaine also helps support liver function through its role in stimulating the production and export of very low density lipoproteins (VLDL) from the liver.³ Methylation Support contains the physiologically active forms of vitamin B₆, folate and vitamin B₁₂, B vitamins involved in tissue formation, red blood cell formation, and macronutrient metabolism, respectively.⁴ As a result of their interrelated pathways, it is important to have metabolic balances between choline, betaine, homocysteine, vitamin B₆, vitamin B₁₂ and folate.⁵

REFERENCES
1. Selhub, J. Food and Nutrition Bulletin. 2008; 29(2 Suppl): S116-S125.
2. Olthof, MR, van Vliet, T, Boelsma, E, Verhoef, P.  J. Nutr. 2003; 133: 4135–4138.
3. Craig, SAS. Am J Clin Nutr. 2004; 80: 539–549.
4. Combs, GF. (2012). The Vitamins (4th ed.). USA: Elsevier.
5. Michel, V, Yuan, Z, Ramsubir, S, Bakovic, M. Exp Biol Med. 2006; 231: 490–504.