HMF Natogen

Contributes to a natural healthy gut flora in young children
• Includes 3 billion CFU per dose from: Lactobacillus acidophilus (CUL-60), Lactobacillus acidophilus (CUL-21), Lactobacillus paracasei (CUL-08), Bifidobacterium animalis subsp. lactis (CUL-62)

HMF Natogen is a combination of four strains of proprietary human-sourced probiotics that promotes intestinal health in young children. Babies born preterm, by Caesarian section, or those exposed to peri- or postnatal antibiotics display reduced colonization of intestinal bacteria.¹ Probiotics are safe for young children and effectively colonize the intestines, critical barriers that selectively allow absorption or promote the excretion of dangerous substances.² The human intestinal tract contains more than 400 bacterial species, and the bacterial balance needs to be maintained for healthy intestines.³ Probiotics compete with pathogenic bacteria for colonization of the gastrointestinal tract and promote the presence of beneficial bacteria.^2,3 In addition to decreasing bacterial survival, probiotics strengthen the epithelial barrier.² They control permeability by mediating tight junction integrity, and prevent pathogenic adherence to epithelial cells by increasing mucin release on intestinal surfaces.² Collectively, this decreases the entry of bacteria from the intestine into circulation.² Probiotics transiently impact the host’s microflora; once their ingestion ends, their counts decrease or disappear.⁴ As the microflora composition in children is relatively unchanged after infancy, it significantly depends on the diet, even more so than in adults.¹

REFERENCES
1. Thomas, DW, Greer, FR. Pediatrics. 2010; 126(6): 1217-1231.
2. Saulnier, N, Zocco, MA, Di Caro, S, Gasbarrini, G, Gasbarrini, A. Genes & Nutrition. 2006; 1(2): 107-116.
3. Nagpal, R, Yadav, H, Kumar, M, Jain, S, Yamashiro, Y, Marotta, F. (2013). In Otles, S. (Ed.), Probiotics and Prebiotics in Food, Nutrition and Health (pp. 1-24). Boca Raton, FL: CRC Press.
4. Saavedra, JM. Nutrition in Clinical Practice. 2007; 22: 351-365.