{"product_id":"calm-mind-60ct","title":"Calm Mind, 60ct","description":"\u003cp\u003eCalm Mind combines clinically studied saffron (affron®) and curcumin (Theracurmin®) extracts to support a positive mood, a calm state of mind, and emotional well-being. With continued use, saffron also supports healthy sleep.\u003c\/p\u003e\n\u003cbr\u003e\n\u003cdiv class=\"description product-description\" data-model=\"XLite\\Model\\Product\" data-identifier=\"65737\" data-property=\"description\"\u003e\n\u003cp\u003eCalm Mind combines two clinically studied botanical extracts, saffron (affron®) and curcumin (Theracurmin®), to support a positive mood, a calm state of mind and emotional well-being. In a double-blind trial involving 128 adults self-reporting low mood, saffron (affron®, 28 mg\/day) resulted in a significant decrease in negative mood and symptoms related to stress after 4 weeks compared to placebo. Other studies indicate that saffron also supports sleep with continued use.\u003c\/p\u003e\n\u003cp\u003eThe regulation of mood and emotional state is influenced by the immune system, and emerging research indicates an impactful role of immune mediators known as cytokines. Lower plasma levels of certain cytokines, such as IL-6 and TNF-α, are associated with positive mood and emotional well-being. In preclinical models, curcumin moderates the production of the cytokines IL-1β, IL-6, and TNF-α, and moderates pro-inflammatory cytokine pathways in the brain. However, the low oral bioavailability of curcumin may limit its ability to support brain function. Theracurmin® is 27 times more bioavailable than standard curcumin. In a study of 40 adults (51–84 years of age), Theracurmin® containing 90 mg curcumin twice daily for 18 months significantly improved short-term, verbal and visual memory and attention.‡\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Benefits:‡\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupports a healthy mindset\u003c\/li\u003e\n\u003cli\u003eSupports a positive outlook\u003c\/li\u003e\n\u003cli\u003ePromotes a calm state of mind\u003c\/li\u003e\n\u003cli\u003eSupports sleep with continued use\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFree From:\u003c\/strong\u003e Pure Encapsulations® products are formulated using high-quality, pure ingredients, free from unnecessary additives and many common allergens including wheat, soy*, dairy*, eggs, artificial colors and sweeteners, coatings and shellacs, GMOs††, tree nuts, peanuts and sesame, unnecessary binders, fillers and preservatives, magnesium stearate, gluten, and trans fat and hydrogenated oils.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eKell G, et al. \u003cem\u003eComplement Ther Med.\u003c\/em\u003e 2017 Aug;33:58-64.\u003c\/li\u003e\n\u003cli\u003eNishide A, et al. \u003cem\u003eJpn Pharmacol Ther.\u003c\/em\u003e 2018;46:8.\u003c\/li\u003e\n\u003cli\u003eLopresti AL, et al. \u003cem\u003eSleep Med.\u003c\/em\u003e 2021 Oct;86:7-18.\u003c\/li\u003e\n\u003cli\u003eLopresti AL et al. \u003cem\u003eJ Clin Sleep Med.\u003c\/em\u003e 2020 Jun 15;16(6):937-947.\u003c\/li\u003e\n\u003cli\u003eHassamal S. \u003cem\u003eFront Psychiatry.\u003c\/em\u003e 2023 May 11;14:1130989.\u003c\/li\u003e\n\u003cli\u003eFan N, et al. \u003cem\u003eHum Psychopharmacol.\u003c\/em\u003e 2017 Jul;32(4).\u003c\/li\u003e\n\u003cli\u003eFan C, et al. \u003cem\u003eNeuroscience.\u003c\/em\u003e 2018 Nov 10;392:92-106.\u003c\/li\u003e\n\u003cli\u003eWang Z, et al. \u003cem\u003eBehav Brain Res.\u003c\/em\u003e 2014 Nov 1;274:282-90.\u003c\/li\u003e\n\u003cli\u003eSasaki H, et al. \u003cem\u003eBiol Pharm Bull.\u003c\/em\u003e 2011;34(5):660-5.\u003c\/li\u003e\n\u003cli\u003eSmall GW, et al. \u003cem\u003eAm J Geriatr Psychiatry.\u003c\/em\u003e 2018 Mar;26(3):266-277.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003csmall\u003eTheracurmin® is a registered trademark of Theravalues Corporation used under license by Pure Encapsulations. Affron® \u0026amp; Lepticrosal ides™ are trademarks owned by Pharmactive Biotech Products S.L.U.\u003c\/small\u003e\u003c\/p\u003e\n\u003cp\u003e\u003csmall\u003e‡This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/small\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eUnit Size:\u003c\/strong\u003e 60 Capsules\u003c\/p\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSupplement FactsServing Size 1 CapsuleServings Per Container 60IngredientAmount Per Serving% Daily ValueTheracurmin® turmeric (Curcuma longa L.) extract (rhizome) (standardized to contain 30% curcumin)300 mg*Affron® saffron (Crocus sativus) extract (stigma) (standardized to contain 3.5% Lepticrosal ides™)15 mg** Daily value (DV) not established.Other Ingredients: Hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water), ascorbyl palmitate.Theracurmin® is a registered trademark of Theravalues Corporation used under license by Pure Encapsulations. Affron® \u0026amp; Lepticrosal ides™ are trademarks owned by Pharmactive Biotech Products S.L.U.Manufactured by: Pure Encapsulations, 490 Boston Post Road, Sudbury, MA | 1-800-753-2277 | www.PureEncapsulations.com\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":47461403426972,"sku":"P358-60","price":44.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0473\/2407\/0044\/files\/calm_20mind_201.webp?v=1787528703","url":"https:\/\/primenaturalfoods.ca\/products\/calm-mind-60ct","provider":"Prime Natural Foods","version":"1.0","type":"link"}