Collagen matrix is mainly produced by fibroblasts throughout connective tissue and epithelial cells, which makes up 28 different types of collagens. The different collagens and the structure they form have the purpose to help tissues resist stretching. Fibroblasts are connective tissue cells that are responsible for producing and organizing the collagen matrix. Collagen fibers, fibrils, epithelial and molecules (triple helices), a-chains and amino acids are the mechanism of collagen formation and biosynthesis that activates the fibroblast cell membrane to produce healthy connective tissue within the entire extracellular matrix (ECM). There are 6 constituents that all work together in synergy throughout the fibroblast system. Hyaluronic acid, enzymes, extracellular matrix, collagen fibrils, elastin, and growth factors, which all play an intricate role in healthy connective tissue.